Friday, August 2, 2013

Phantom Limb Syndrome

The ability to sense our environment is something that many of us take for granted. It's the simple, general things that we encounter every day; this pillow feels soft, the concrete is hard, snow is cold. But what if you were feeling things with a part of you that wasn't there?

No, this isn't something from a science fiction show, it's a real disorder that often occurs in amputees called phantom limb syndrome. And it's more common than you probably think; 80 percent of amputees will experience this phenomenon at some point. 

Symptoms
The symptoms are very straight forward – if a person can feel something from a part of the body where a limb is not present, then they have phantom limb. The types of sensations are divided between non-painful and painful. Non-painful sensations are very much like the feelings described above. They can range from feeling differences in temperature to itching. The latter subdivision includes pains such burning and prickling.


The painful feelings are unfortunately the most common sensations related to phantom limb syndrome. Oftentimes the pain is intrusive and debilitating. It can severely interfere with daily life and is difficult to effectively cure.

Cause
Normally the body is able to interpret sensations through sensory receptors under the skin. These receptors create electrical signals that are able to be carried from the peripheral nervous system to the central nervous system, where it can be interpreted and responded to accordingly.

Amputees obviously do not have these receptors. So what’s triggering the brain’s response?

Scientist Vilayanur S. Ramachandran believes that the syndrome has something to do with neurons changing connections in the brain (a process called neuroplasticity). Basically, certain sections of the brain are used for specific areas of sensory input. When area is lacking any sort of stimulation because of the amputation, other parts of the brain are connected to this area.


For example, in one of Ramachandran’s experiments he discovered that an arm amputee was receiving signals from sensory receptor in the face. The section of the brain used for interpreting messages from the arm was not receiving any input, so neurons connected to the sensory receptors for the face.

Treatments
A very basic form of relief for those that suffer from the painful effects of phantom limb is pain medication. Of course this is not very helpful for those that suffer from non-painful effects and even those on medication may not fully be pain free.

An interesting outlet for relief can be found in a very specific type of acupuncture. This traditional medical technique has been used for thousands of years for a variety of ailments and disease. In phantom limb specifically, a small, precise prick of the ear has been known to alleviate pain. There are also a few pin pricks on the scalp, but the ear is the key. This treatment is usually supplemental to medication.
Mirror treatment
 A newer treatment that is now commonly associated with phantom limb relief is mirror-box therapy. It requires patients to insert their intact limb in a box with a mirror where they cannot see their amputated limb. The effectiveness is questionable, but has been noted to help at least 60 percent of patients in two different studies. 





Wednesday, July 31, 2013

Breastfeeding Promotes Beneficial Gut Bacteria in Infants

After reading the article Gut Microbes for Life by Ed Young that discussed the relative long term stability of our gut flora I wondered if the way a mother chooses to feed her baby had any effect on the bacterial make-up of an infant’s gut and if that had any effect on long term health related to gastrointestinal diseases. All major medical associations recommend exclusive breastfeeding for 6 months followed by continued breastfeeding with the addition of age appropriate foods until at least 1 year of age. The health benefits of breastfeeding to both mom and baby have been researched extensively and are now accepted by much of the general population. Healthy People 2020 goals are to have 81.9% of moms initiate breastfeeding, 46.2% exclusively breastfeeding at 3 months, 60.6% breastfeeding at 6 months, 25.5% exclusive breastfeeding at 6 months, and 34.1% breastfeeding at 1 year.  Even with the research highlighting the benefits of breastfeeding many mothers choose to formula feed their infants. The CDC 2012 Breastfeeding Report card shows only 76.9% of mothers initiating breastfeeding, 36% exclusive at 3 months, 47.3% breastfeeding at 6 months, 16.3% exclusive breastfeeding at 6 months, and only 25.2% at 1 year.

The intestinal flora is important for the development of the immune system and normal intestinal structure and function. There appears to be many different ways in which breastmilk promotes the development of healthy gut flora while protecting infants against both short-term and long-term intestinal issues.  Breastfeeding promotes a higher number of Bifidobacteria. Bifidobacteria inhibits the growth of harmful bacteria and pathogens. The gut of a breastfed baby has a lower pH which promotes the growth of Bifidobacteria and also inhibits the growth of harmful bacteria. Formula fed infants have more harmful bacteria such as coliforms, enterococci and bacteroides. As formula fed infants age, they also will get more Bifidobacteria but the breastfed infants level remain many times higher.
Bifidobacteria

Another way that breastfeeding helps promote gut health is through the development of biofilms that form a barrier against pathogens and infections. This is especially important for infants since the junctions of the gut mucosa are pretty open and allow pathogens to pass through easily. This is further augmented by sIgA that the mother produces and passes on through the breastmilk. These antibodies are specific to pathogens in the infant environment that have the potential to cause disease. This sIgA coats the gut and provides another layer of protection.
Breastmilk also contains human milk oligosaccharides, complex carbohydrates that are not in formula. These oligosaccharides help to promote healthy gut bacteria that initially protect the infant from infections. As the infant gets older, the oligosaccharides change and produce different fatty acids that help the immune system develop that provides protection against food allergies and asthma.
Research is just beginning to look at how the difference in bacteria, pH, biofilms and immunologic development from breastfeeding is affecting different intestinal disease. One study looked specifically at infants who had a high-risk for the development of Celiac Disease. Breastfeeding was shown to decrease the bacteria that were associated with the development of Celiac Disease. Breastfeeding increased the prevalence of B. uniformis bacteria that was more often seen in the low-risk group. A meta-analysis of research showed that breastfeeding was associated with a decreased risk of both Crohn's Disease and Ulcerative Colitis.                    

http://ajcn.nutrition.org/content/80/5/1342.full

 


Just one bottle won’t hurt—or will it? Marsha Walker, RN, IBCLC  

Monday, July 29, 2013

Diet Drugs: A Quick View


Diet Drugs: A Quick View


Having a healthy body weight can reduce the risk of medical conditions: diabetes, heart disease, high blood pressure, arthritis, and even some cancers. The benefits of having a healthy weight are apparent, but are people harming themselves to achieve it? Studies have revealed that one in five women have used diet drugs as part of their diet plan when trying to lose weight. There are several types of diet drugs that all claim to make you skinny fast. Many of these drugs have very serious side effects and show very little results. The Mayo Clinic did a very good job creating a list of some of the more popular drugs, their claim, effectiveness, and side effects associated with the drug (see link below). I have chosen two different drugs that claim to reduce body weight using different methods to investigate. Alli is a very popular diet drug that hopes to help people lose weight by decreasing absorption of dietary fat. Another diet drug is Chromium, which is used to decrease appetite and increase calories burning. Both weight loss drugs come with the recomendation that the individual follow a low fat diet and exercise plan, for best results. In fact, individuals taking Alli are recommended to eat meals with less than 15 grams of fat to reduce the risk of side effects. There about 14 grams of fat in a slice of Pizza Hut pizza. There are about 9 grams of fat in a hamburger at McDonalds (that's without cheese). How many hamburgers does it take for you to get full? Now that you have an idea of what these diet drugs do, lets see how they work:

 

 
ALLI                                  

 
Alli is an over the counter drug that has the same drug as a prescription drug called Orlistat (Xenical). Alli has been proven to be effective, but the outcome is more modest than its prescription friend, Xenical.

 
Alli works by reducing the amount of fat that is absorbed into the body.  As we know enzymes in the stomach breakdown fat into smaller particles to be absorbed. Alli attaches itself to the enzyme, stopping it from making contact with the fat and breaking it down, causing 25% less fat to be absorbed. Undigested fat is then passed out of the body.

 
Side effects of Alli include: Loose stool, oily stool, frequent or hard- to- control bowel movements;

There have been some reports of severe liver damage associated with Alli as well.

 

 
     Caption: "Please excuse me from being late I have explosive diarrhea. -K-"

                                                                                                 


                            
Chromium

 
Chromium is a mineral that is already found in the body, in trace amounts. Chromium helps insulin be more efficient in to body. Insulin is critical to the metabolism of glucose. Chromium is believed to assist glucose transition into muscle cells instead of fat cells. A chromium supplement has been produced in hopes that an increase of this mineral will speed up its effect on the body.

 
The mayo clinic found Chromium supplements are probably ineffective.

 
Side effects for Chromium supplements include:

Headache, insomnia, irritability, mood changes, and cognitive dysfunction.




**It is important to fully research any diet drug and contact your doctor before starting these types of medication**


http://www.myalli.com/alli/alli/
http://www.mayoclinic.com/health/weight-loss/HQ01160/METHOD=print
http://ods.od.nih.gov/factsheets/Chromium-HealthProfessional/
http://buyorlistat120mg.net/
http://www.ehow.com/how-does_4566797_chromium-picolinate-help-weight-loss.html

Sunday, July 28, 2013

Charcot Marie Tooth Disease

For my blogging assignment I decided to add on to our topic of diseases.  I chose a different disease, one that has not yet been researched for our class.  Though this disease is new to the class it is not new to me.  The disease does not affect me, but one that I love very dearly and consider to be my best friend.  I have always known that the individual had the disease, but never knew the full extent of its effects.  This five minute YouTube video briefly explains the disease and the emotional toll that it can take on a family.
Video on effects of CMT
                Charcot-Marie-Tooth Disease (CMT) is a disease that affects the peripheral neuropathy.  This more simply put means that the disease attacks the nerves throughout the body that control sensitivity and the electrical signals in the myelin sheath (for most forms of the disease).  The peripheral nerves throughout the body connect the brain and spine to extremities of the body.  These nerves alert the body of sensations such as touch, pain, heat, and sound.  Charcot-Marie-Tooth Disease is due to chromosome 17, gene PMP22 (for CMT1), being damaged and the disease causes atrophy to the muscles in the feet, legs, and hands.  Unlike any other muscular dystrophy disease CMT affects the nerves and not the muscles directly.
Symptoms:

  • ·         High Arches in feet
  • ·         Drop foot
  • ·         Hammer Toes
  • ·         Weak ankles
  • ·         Spasms
  • ·         Cramping
  • ·         Sensitivity in the feet and hands
  • ·         Clumsiness
  • ·         Overall weakness in the legs


After knowing a person with this disease and knowing that they have the disease it is easy to recognize that they have it.  When you know what to look for it is very easy to see the disease present throughout their body.

Treatment
CMT is the most commonly inherited neuropathy and is present in an estimated 2.6 million people.  Therefore, there are a good amount of treatments to individuals with the disease.   The main treatment after the disease is diagnosed is for the individual to see the podiatrist for treatment for their ankles and feet.  After this treatment the patient, depending on severity, is directed to an occupational therapist for exercises to increase strength within the muscles and how to stretch them to avoid cramping and spasms.  It is highly recommended for those with the disease to keep up muscle use as much as they can.  The more that they use their muscles and maintain movement, the more their nerves and muscles are used keeping them from deteriorating. 
Inheritance
CMT is inherited in the autosomal dominant manner.  This means that in order to inherit the disease you only have to receive one allele to have the disease.  Since it is autosomal that means that it doesn’t matter if you are a male or a female you are at risk of inheriting the disease.  There is more than one type of CMT that can be inherited and each type varies in severity, the symptoms that are prevalent, and how the disease is caused.  In total there are approximately 18 different variations of the disease. 
Is there a cure?
Currently there is no cure CMT, though the CMT Association (CMTA) is an association that actively funds research for the cure for CMT.  The best way that the disease is treated/cured is through trips to the doctor, surgeries, and therapy.  I foresee the best cure to come will be stopping it from being inherited through manipulation of the allele that causes the disease from being passed down to the offspring.

Sources:

viruses

Viruses can be found everywhere. However viruses are not living. Theses organisms are not living but as soon as they find a host they become active. Viruses are very interesting in that they only stick to things that they know. For instance plant viruses only affect plants and animal viruses only affect animals. Viruses are very small. They can be up to 10,000 times smaller than bacteria, or about one millionth of an inch. They are made up of a collection of genetic material encased in protein called capsid. Sometimes the capsid are covered by more proteins, lipids, and carbohydrates that might have spikes to help the viruses attach to host cells. This picture shows the different layers that are possible on a virus.

Viruses enter the body through the nose, mouth,  through your skin, or any opening in the body and they find a cell to be their host. So this why when somebody sneezes near you, you then get the virus, because the virus from their sneeze then goes in your nose or onto your skin. Once the virus gets inside the cell it makes a new virus and leaves that cell to go to contaminate other healthy cells in the body. When the virus leaves the cells it can leave in two ways. The first way is to break the host cell open, in this situation it destroys the host cell. The other way the virus can get out is to pinch out from the cell membrane, in this situation the host cell does not get destroyed. Either way the virus leaves it is still affecting the healthy cell and this is how viruses make you sick because they ruin the healthy cells. Doctors have made vaccines to prevent viruses because antibiotics do not get rid of viruses but some can stop them from spreading. So it is very hard to get rid of viruses. Sometimes they leave the body within a few weeks and other times they stay for years or even a lifetime. So since it is so hard to get rid of viruses the best thing to do is to prevent them. The first step in preventing viruses is good hygiene. The other way of prevention is vaccines. A vaccine is a small dose of the actual virus to get the body to build antibodies to fight against the specific germ. Some people also use home remedies to get rid of viruses or to prevent them. Most people are willing to do whatever it takes to get rid of viruses or to prevent them since they are so hard to get rid of and can become something very serious.